Publications
Current S²C² Related Publications
- Smith, E.M., Ferrell, S., Tokars, V.L., Mondragon, A. (August 2022) "Structures of an active type III-A CRISPR effector complex." Structure 30, 8, 1109-1128.e6 DOI: https://doi.org/10.1016/j.str.2022.05.013
- Yu, Z., Chen, J., Takagi, E., Wang, F., Saha, B., Liu, X., Joubert, L.-M., Gleason, C.E., Jin, M., Li, C., Nowotny, C., Agard, D., Cheng, Y., Pearce, D. (August 2022) "Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt." Journal of Biological Chemistry 102288. Epub ahead of print DOI: 10.1016/j.jbc.2022.102288
- Rutledge, H.L., Cook, B.D., Nguyen, H.P.M.; Herzik, Jr, M.A., Tezcan, F.A. (July 2022) "Structures of the nitrogenase complex prepared under catalytic turnover conditions." Science eabq7641 Online ahead of print DOI: 10.1126/science.abq7641
- Kim, D.S., Watkins, A., Bidstrup, E., Lee, J., Topkar, V., Kofman, C., Schwarz, K.J., Liu, Y., Pintilie, G., Roney, E., Das, R., Jewett, M.C. (July 2022) "Three-dimensional structure-guided evolution of a ribosome with tethered subunits." Nat Chem Biol Epub ahead of print. DOI: 10.1038/s41589-022-01064-w
- Fontana, P., Dong, Y., Pi, X., Tong, A.B., Hecksel, C.W., Wang, L., Fu, T.-M., Bustamante, C., Wu, H. (June 2022) "Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold." Science 10;376(6598):eabm9326 DOI: 10.1126/science.abm9326
- Yelshanskaya, M.V., Patel, D.S., Kottke, C.M., Kurnikova, M.G., Sobolevsky, A.I. (April 2022) "Opening of glutamate receptor channel to subconductance levels." Nature 605, 172-178 DOI: 10.1038/s41586-022-04637-w
- Abskharon, R., Sawaya, M.R., Boyer, D.R., Cao, Q., Nguyen, B.A., Cascio, D., Eisenberg, D.S. (April 2022) "Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation." Proc Natl Acad Sci 119 (15) e2119952119 DOI: 10.1073/pnas.2119952119
- Kafai, N.M., Williamson, L.E., Binshtein, E., Sukupolvi-Petty, S., Gardner, C.L., Liu, J., Mackin, S., Kim, A.S., Kose, N., Carnahan, R.H., Jung, A., Droit, L., Reed, D.S., Handley, S.A., Klimstra, W.B., Crowe, J.E., Diamond, Michael S. (April 2022) "Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge." J Exp Med 219 (4): e20212532 DOI: https://doi.org/10.1084/jem.2021252
- Koo, C.W., Tucci, F.J., He, Y., Rosenzweig, A.C. (March 2022) "Recovery of particulate methane monooxygenase structure and activity in a lipid bilayer." Science 18;375(6586):1287-1291 DOI:
- 10.1126/science.abm3282
- Tsai, K., Stojkovic, V., Lee, D.J., Young, I.D., Szal, T., Klepacki, D., Vazquez-Laslop, N., Mankin, A.S., Fraser, J.S., Fujimori, D.C (February 2022) "Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics." Nat. Struct. Mol. Biol. 29, 162-171 DOI: 10.1038/s41594-022-00723-9
- Zhou, W., Bammes, B., Mitchell, P.G., Betz, K., Chiu, W. (January 2022) "Electron crystallography of chiral and non-chiral small molecules." Ultramicroscopy. 2021;232:113417. DOI: 10.1016/j.ultramic.2021.113417 https://doi.org/10.1016/j.ultramic.2021.113417
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Klykov, O., Gangwar, S.P., Yelshanskaya, M.V., Yen, L., Sobolevsky, A.I. (December 2021) "Structure and desensitization of AMPA receptor complexes with type II TARP γ5 and GSG1L. Mol. Cell." 81(23):4771-4783. https://doi.org/10.1016/j.molcel.2021.09.030
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Cogan DP, Zhang K, Li X, Li S, Pintilie GD, Roh SH, Craik CS, Chiu W, Khosla C. (November 2021) "Mapping the catalytic conformations of an assembly-line polyketide synthase module." Science. 374(6568):729-34. DOI: 10.1126/science.abi8358
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Neuberger, A., Nadezhdin, K.D., Sobolevsky, A.I. (November 2021) "Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole." Nat. Commun. 12(1):6284. DOI: 10.1038/s41467-021-26608-x
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Harris, J.A., Faust, B., Gondin, A.B., Damgen, M.A., Suomivuori, C-M., Veldhuis, N.A., Cheng, Y., Dror, R.O., Thal, D.M., Manglik, A.. (October 2021) "Selective G protein signaling driven by substance P-neurokinin receptor dynamics." Nat. Chem. Biol. 18: 109-15. DOI: 10.1038/s41589-021-00890-8
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Sheedlo, M.J., Durie, C.L., Chung, J.M., Chang, L., Roberts, J., Swanson, M., Lacy, D.B., Ohi, M.D. (September 2021) "Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS. eLife." 10:e7042. doi: 10.7554/eLife.70427
- Zhang, K., Zheludev, I.N., Hagey, R.J., Haslecker, R., Hou, Y.J., Kretsch, R., Pintilie, G.D., Rangan, R., Kladwang, W., Li, S., Wu, M.T., Pham, E.A., Bernardin-Souibgui, C., Baric, R.S., Sheahan, T.P., D'Souza, V., Glenn, J.S., Chiu, W., Das, R. (August 2021) "Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome." Nat Struct Mol Biol. DOI: 10.1038/s41594-021-00653-y.
- Ericksen, J., Li, F., Stroud, R.M., and Edwards, R.H. (July 2021) "Allosteric Inhibition of a Vesicular Glutamate Transporter by an Isoform-Specific Antibody." Biochemistry 60, 32, 2463-2470 DOI: https://doi.org/10.1021/acs.biochem.1c00375
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Hu, W., Parkinson, C., and Zheng, H. (June 2021) "Mechanistic Insights Revealed by YbtPQ in the Occluded State." bioRxiv 2021.06.15.448544 DOI: https://doi.org/10.1101/2021.06.15.448544 (preprint)
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He Y, Wang Y, Liu B, Helmling C, Susac L, Cheng R, Hong Zhou Z, Feigon J. (May 2021) "Structures of telomerase at several steps of telomere repeat synthesis." Nature 593: 454-59. doi: 10.1038/s41586-021-03529-9.
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Zhang, K., Li, S., Pintilie, G., Chmielewski, D., Schmid, M.F., Simmons, G., Jin, J., and Chiu, W. (November 2020) "A 3,4-Å cryo-electron microscopy structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles." QRB Discovery 1, E11. DOI: https://doi.org/10.1017/qrd.2020.16
- Zhang, K., Pintilie, G.D., Li, S., Schmid, M.F., and Chiu, W. (November 2020) "Resolving individual atoms of protein complex by cryo-electron microscopy." Cell Res https://doi.org/10.1038/s41422-020-00432-2 PMC7605492
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Fromm, S.A., Lawrence, R.E., and Hurley, J.H. (August 2020) "Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9." Nature Structural & Molecular Biology 27, 1017-1023 DOI: https://doi.org/10.1038/s41594-020-0490-9
- Fan, C., Kaiser, J.R., and Rees, D.C. (August 2020) "A structural framework for unidirectional transport by a bacterial ABC exporter."
- Kumar, A., Basak, S., Rao, S., Gicheru, Y., Mayer, M.L., Sansom, M.S.P., and Chakrapani, S. (July 2020). "Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs." Nature Communications 11, 3752; DOI: https://doi.org/10.1038/s41467-020-17364-5
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Zhang, K., Zheludev, I., Hagey, R., Wu, M., Haslecker, R., Hou, Y., Kretsch, R., Pintilie, G., Rangan, R., Kladwang, W., Li, S., Pham, E., Bernardin, C., Baric, R., Sheahan, T., Dsouza, V., Glenn, J., Chiu, W., and Das, R. (July 2020) "Cryo-electron Microscopy and Exploratory Antisense Targeting of the 28-kDa Frameshift Stimulation Element from the SARS-CoV-2 RNA Genome." bioRxiv 2020.07.18.209270; DOI: https://doi.org/10.1101/2020.07.18.209270 (preprint)
S²C² Publications Acknowledgement
Any use of the resources at S²C² requires acknowlegement in publications as follows: “Some of this work was performed at the Stanford-SLAC Cryo-EM Center (S²C²), which is supported by the National Institutes of Health Common Fund Transformative High Resolution Cryo-Electron Microscopy program (U24 GM129541). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health."