Current S²C²  Related Publications

  1. Smith, E.M., Ferrell, S., Tokars, V.L., Mondragon, A. (August 2022) "Structures of an active type III-A CRISPR effector complex." Structure 30, 8, 1109-1128.e6 DOI:
  2. Yu, Z., Chen, J., Takagi, E., Wang, F., Saha, B., Liu, X., Joubert, L.-M., Gleason, C.E., Jin, M., Li, C., Nowotny, C., Agard, D., Cheng, Y., Pearce, D. (August 2022) "Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt." Journal of Biological Chemistry 102288. Epub ahead of print DOI:  10.1016/j.jbc.2022.102288
  3. Rutledge, H.L., Cook, B.D., Nguyen, H.P.M.; Herzik, Jr, M.A., Tezcan, F.A. (July 2022) "Structures of the nitrogenase complex prepared under catalytic turnover conditions." Science eabq7641 Online ahead of print DOI: 10.1126/science.abq7641
  4. Kim, D.S., Watkins, A., Bidstrup, E., Lee, J., Topkar, V., Kofman, C., Schwarz, K.J., Liu, Y., Pintilie, G., Roney, E., Das, R., Jewett, M.C. (July 2022) "Three-dimensional structure-guided evolution of a ribosome with tethered subunits." Nat Chem Biol  Epub ahead of print. DOI: 10.1038/s41589-022-01064-w
  5. Fontana, P., Dong, Y., Pi, X., Tong, A.B., Hecksel, C.W., Wang, L., Fu, T.-M., Bustamante, C., Wu, H. (June 2022) "Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold." Science 10;376(6598):eabm9326 DOI: 10.1126/science.abm9326
  6. Yelshanskaya, M.V., Patel, D.S., Kottke, C.M., Kurnikova, M.G., Sobolevsky, A.I. (April 2022) "Opening of glutamate receptor channel to subconductance levels."  Nature 605, 172-178 DOI: 10.1038/s41586-022-04637-w
  7. Abskharon, R., Sawaya, M.R., Boyer, D.R., Cao, Q., Nguyen, B.A., Cascio, D., Eisenberg, D.S. (April 2022) "Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation." Proc Natl Acad Sci 119 (15) e2119952119 DOI: 10.1073/pnas.2119952119
  8. Kafai, N.M., Williamson, L.E., Binshtein, E., Sukupolvi-Petty, S., Gardner, C.L., Liu, J., Mackin, S., Kim, A.S., Kose, N., Carnahan, R.H., Jung, A., Droit, L., Reed, D.S., Handley, S.A., Klimstra, W.B., Crowe, J.E., Diamond, Michael S. (April 2022) "Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge." J Exp Med 219 (4): e20212532 DOI:
  9. Koo, C.W., Tucci, F.J., He, Y., Rosenzweig, A.C. (March 2022) "Recovery of particulate methane monooxygenase structure and activity in a lipid bilayer." Science 18;375(6586):1287-1291 DOI: 
  10. 10.1126/science.abm3282 
  11. Tsai, K., Stojkovic, V., Lee, D.J., Young, I.D., Szal, T., Klepacki, D., Vazquez-Laslop, N., Mankin, A.S., Fraser, J.S., Fujimori, D.C (February 2022) "Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics." Nat. Struct. Mol. Biol. 29, 162-171 DOI: 10.1038/s41594-022-00723-9
  12. Zhou, W., Bammes, B., Mitchell, P.G., Betz, K., Chiu, W. (January 2022) "Electron crystallography of chiral and non-chiral small molecules." Ultramicroscopy.  2021;232:113417. DOI: 10.1016/j.ultramic.2021.113417
  13. Klykov, O., Gangwar, S.P., Yelshanskaya, M.V., Yen, L., Sobolevsky, A.I. (December 2021) "Structure and desensitization of AMPA receptor complexes with type II TARP γ5 and GSG1L. Mol. Cell." 81(23):4771-4783.
  14. Cogan DP, Zhang K, Li X, Li S, Pintilie GD, Roh SH, Craik CS, Chiu W, Khosla C. (November 2021) "Mapping the catalytic conformations of an assembly-line polyketide synthase module." Science. 374(6568):729-34. DOI: 10.1126/science.abi8358
  15. Neuberger, A., Nadezhdin, K.D., Sobolevsky, A.I. (November 2021) "Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole." Nat. Commun. 12(1):6284. DOI: 10.1038/s41467-021-26608-x
  16. Harris, J.A., Faust, B., Gondin, A.B., Damgen, M.A., Suomivuori, C-M., Veldhuis, N.A., Cheng, Y., Dror, R.O., Thal, D.M., Manglik, A.. (October 2021) "Selective G protein signaling driven by substance P-neurokinin receptor dynamics." Nat. Chem. Biol. 18: 109-15. DOI: 10.1038/s41589-021-00890-8
  17. Sheedlo, M.J., Durie, C.L., Chung, J.M., Chang, L., Roberts, J., Swanson, M., Lacy, D.B., Ohi, M.D. (September 2021) "Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS. eLife." 10:e7042. doi: 10.7554/eLife.70427
  18. Zhang, K., Zheludev, I.N., Hagey, R.J., Haslecker, R., Hou, Y.J., Kretsch, R., Pintilie, G.D., Rangan, R., Kladwang, W., Li, S., Wu, M.T., Pham, E.A., Bernardin-Souibgui, C., Baric, R.S., Sheahan, T.P., D'Souza, V., Glenn, J.S., Chiu, W., Das, R.  (August 2021) "Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome." Nat Struct Mol BiolDOI: 10.1038/s41594-021-00653-y.
  19. Ericksen, J., Li, F., Stroud, R.M., and Edwards, R.H. (July 2021) "Allosteric Inhibition of a Vesicular Glutamate Transporter by an Isoform-Specific Antibody." Biochemistry 60, 32, 2463-2470 DOI:
  20. Hu, W., Parkinson, C., and Zheng, H. (June 2021) "Mechanistic Insights Revealed by YbtPQ in the Occluded State." bioRxiv 2021.06.15.448544 DOI: (preprint)
  21. He Y, Wang  Y, Liu B, Helmling C, Susac L, Cheng R, Hong Zhou Z, Feigon J.  (May 2021) "Structures of telomerase at several steps of telomere repeat synthesis." Nature 593: 454-59. doi:  10.1038/s41586-021-03529-9.
  22. Zhang, K., Li, S., Pintilie, G., Chmielewski, D., Schmid, M.F., Simmons, G., Jin, J., and Chiu, W. (November 2020) "A 3,4-Å cryo-electron microscopy structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles." QRB Discovery 1, E11. DOI:
  23. Zhang, K., Pintilie, G.D., Li, S., Schmid, M.F., and Chiu, W. (November 2020) "Resolving individual atoms of protein complex by cryo-electron microscopy." Cell Res PMC7605492  
  24. Fromm, S.A., Lawrence, R.E., and Hurley, J.H. (August 2020) "Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9." Nature Structural & Molecular Biology 27, 1017-1023 DOI:
  25. Fan, C., Kaiser, J.R., and Rees, D.C. (August 2020) "A structural framework for unidirectional transport by a bacterial ABC exporter." 
  26. Kumar, A., Basak, S., Rao, S., Gicheru, Y., Mayer, M.L., Sansom, M.S.P., and Chakrapani, S. (July 2020). "Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs." Nature Communications 11, 3752; DOI:
  27. Zhang, K., Zheludev, I., Hagey, R., Wu, M., Haslecker, R., Hou, Y., Kretsch, R., Pintilie, G., Rangan, R., Kladwang, W., Li, S., Pham, E., Bernardin, C., Baric, R., Sheahan, T., Dsouza, V., Glenn, J., Chiu, W., and Das, R. (July 2020) "Cryo-electron Microscopy and Exploratory Antisense Targeting of the 28-kDa Frameshift Stimulation Element from the SARS-CoV-2 RNA Genome." bioRxiv 2020.07.18.209270; DOI: (preprint)


S²C² Publications Acknowledgement

Any use of the resources at S²C² requires acknowlegement in publications as follows: “Some of this work was performed at the Stanford-SLAC Cryo-EM Center (S²C²), which is supported by the National Institutes of Health Common Fund Transformative High Resolution Cryo-Electron Microscopy program (U24 GM129541). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health."